BPC-157 + TB-500 Stack
The classic BPC-157 + TB-500 healing stack — mechanism, dosing, cycle length and safety considerations.
Why the two are stacked
BPC-157 acts locally, promoting angiogenesis and fibroblast migration at the site of injury. TB-500 (a thymosin beta-4 fragment) acts systemically, upregulating actin and improving cell migration across tissues. Together they cover local repair and whole-body recovery, which is why the pairing is the standard healing stack.
Typical dosing
Research protocols commonly run BPC-157 at 250–500 mcg once or twice daily, injected subcutaneously near the injury, alongside TB-500 at 2–2.5 mg twice weekly during a loading phase of four to six weeks, then 2 mg weekly for maintenance.
Cycle length
Most healing cycles run four to eight weeks, matched to the tissue's recovery timeline. Tendon and ligament work generally sits at the longer end. Extending indefinitely is not supported by the available data — cycle off and reassess.
Reconstitution and storage
Reconstitute BPC-157 5 mg with 2 mL of BAC water for 2.5 mg/mL (250 mcg = 10 units). TB-500 5 mg with 2 mL gives 2.5 mg/mL (2.5 mg = 100 units). Store both refrigerated at 2–8 °C and use within about 28 days of reconstitution.
Frequently asked questions
Can BPC-157 and TB-500 be mixed in one syringe?
Many research protocols draw them separately to keep dosing accurate; both are saline-compatible, but separate injections avoid compounding errors.
How long before results?
Reported subjective improvement in soft-tissue pain typically appears within one to three weeks, with structural recovery over the full four-to-eight-week cycle.
Do I inject near the injury?
BPC-157 is commonly injected subcutaneously close to the affected area. TB-500 acts systemically, so site placement matters less.